"a way out," "way of escape," 1Co 10:13 (ek, "out," baino, "to go"), is rendered "issue" in Heb 13:7, RV, for AV, "end," regarding the manner of life of deceased spiritual guides. See END.
"a flowing" (akin to rheo, "to flow"), "an issue," is used in Mar 5:25, Luk 1:8-44. Note: In Mat 22:25, AV, sperma, "seed," is translated "issue" (RV, "seed"). "to cause to go forth" (ek, "out," poreuo, "to cause to go"), is used in the Middle Voice in Rev 1:9-18, of the coming forth of fire, smoke and brimstone from the mouths of the symbolic horses in a vision, AV, "issued" (the RV renders it by the verb "to proceed"). See COME, DEPART, GO, PROCEED.